The researchers developed a technique for producing transplantable liver in the laboratory

Researchers at the Human Genome and Stem Cell Research Center (Hugh sale), Run by the Institute of Bioscience (IB-USP) at the University of S. Paul and Paolo in Brazil, has developed a strategy for laboratory reconstruction and livelihoods.

The Proof of Concept Study was performed with rat survivors. In the next step of their research, scientists will adopt strategies to produce human livelihoods to increase the supply of these organs for future replacement.

Collaborated in studies FAPESP And an article mentioned Published Inside Physics and Engineering: c. “The plan is for human researchers to produce laboratory quality. This will avoid the long expectation of a continuous donor and reduce the risk of organ transplant rejection. Luiz Carlos de Kiers-Jr., The first author of the article told Agossia FAPESP. He is a Postdoctoral Fellow at HUG-CEL, Research Center, Center for Innovation and Promotion (RIDC) Funding by FAPESP.

This method has developed tissue bioengineering techniques in recent years to create organs for transplantation based on erosion and reconstruction. An organ of a dead donor, in this case the liver is treated with various solutions containing detergents or enzymes to remove all the cells from different tissues, leaving only the matrix of the carrier cell with the original structure and size of the organ. The extracellular matrix is ​​then bound to the cells taken from the patient. The strategy avoids the immune system response and the risk of long-term rejection.

“It’s comparable to a ‘reconstructive’ liver transplant. It won’t be rejected because it uses the patient’s own cells and doesn’t need to run immunosuppressants,” he said. Moyna’s magic, Chief investigator of Hugh-Cell and final author of the article.

This technique can also be used to reconstruct organs considered borderline and non-transferable, Kirs-Jr. explained, increasing the supply of organs for patients on the waiting list.

“Many of the organs available for replacement cannot actually be used because the donor died in a traffic accident. The technique can be used to correct them based on their condition.

The synthesis process removes the core components of the extracellular matrix, such as molecules telling cells to multiply and form blood vessels, for example. This weakens the cell adhesion of the extrinsic matrix and compromises re-synthesis.

To overcome this hurdle, HUG-CELL researchers expanded the strategy by introducing an additional phase between refinement and recovery.

Once the rat organisms are isolated and deformed, they attach to an extracellular matrix rich in molecules such as sparks and TGFB1, producing intermediate proteins through liver cells in the laboratory. These proteins are essential for a healthy liver because they help liver cells dilate and form blood vessels.

“The growth of the extrinsic matrix with these molecules makes it more compatible with a healthy liver,” says Kirs-Jr.

External metrics of rat liver are treated with solution and hepatocytes, endothelial cells and mesenchymal cells are introduced into the components. Mesenchymal cells originated from human-infected pluripotent stem cells (IPSCs) produced by reproduction in adult skin cells (or other easily accessible tissue cells) obtained during the reproductive stage of an embryo.

“Studies have shown that differences in human stem cell lineage are part of the liver and it is possible to use these cells to regenerate the differences so that it is effective. This is a testament to the idea that the sugges technique works first,” Jazet said.

Liver cells make a human-featured organ for injection into the outer matrix of the rat liver with a syringe pump. It was born in an incubator for five weeks that mimics the condition of the human body. Analysis showed that external matrix enrichment with SPARC and TGFB1 significantly improved restructuring.

“Liver cells grow more and work more firmly,” Kier-Jr. said. “We plan to build a bioreactor to teach people and research their production potential in the laboratory.”

He said the technique could be adapted to create other organs such as the lungs, heart and skin.

Organ factory

The project is part of a research line followed by HUG-CEL to produce or reconstruct transplant organs using a variety of technologies.

Through this Recruitment or project The pharmaceutical company has partnered with EMS to sponsor research partnerships for technology innovation programs and to support FAPESP (Sওo Paulo Research Foundation).Pete), HUG-CELL researchers aim to repair pig organs such as the kidneys, heart and skin for transplantation into the human body (read more: agency.faps.p/b29771/).

Pigs would be rejected if they were transplanted into humans, so researchers are moving on to other technologies such as 3D printing (read more: AgencyCIAFASPSR / 322222 /) as well as for refining and restoration.

“These are complementary methods. We look forward to seeing the transplant organ factories in the future.”

About SO O Paolo Research Foundation (FAPESP)

The SPO Paolo Research Foundation (FAPESP) is a public organization that works to support scientific research in all areas of knowledge by providing scholarships, fellowships, and grants to researchers affiliated with higher education and research institutions in the state of Sao Paulo, Brazil. FAPESP is aware that very good research can only be done by working with the best researchers internationally. As such, it has established partnerships with funding agencies, higher education, non-governmental organizations and research institutes in other countries known for the quality of research and continues to encourage grant funding to further enhance international cooperation with scientists. You can learn more about AFESP http: // www.FlopBR /N See more AFEPESP news agencies http: // www.AgencyFlopBR /N Many FAPESP programs, awards and research centers help to achieve the latest scientific achievements. You can subscribe to AFESPSP news agency http: // agency.FlopBR /To subscribe.

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